The Mkomazi National Park is located in the northern part of Tanzania, between Moshi and Tanga. The park finds itself in a beautiful setting with both the Pare and Usambara mountains towering above its boundaries. Depending on the weather, Mount Kilimanjaro can also be seen from the park. In terms of vegetation, Mkomazi marks the southern tip of the Sahel zone which resembles that of a dry, desert like landscape. Due to the climate, the vegetation primarily consist of acacia-commiphora woodlands and towards the western mountains the vegetation changes to a dry land forest.

The main source of water in Mkomazi comes from the Umba River in the southeast. Apart from that, the park sees very little precipitation all year round making game drives along the river area definitely worthwhile.